Top 15 Python Development Companies In The U.S. (2025)

Looking for a Python development company in the U.S. that can deliver exceptional results for your project?

That’s why we’ve created this guide – to make your search for the ideal Python development partner easier.

We’ve compiled a list of the top Python development companies in the U.S., covering a wide range of expertise including web application development, AI and machine learning, data engineering, automation, and enterprise solutions.

So without further ado, let’s dive in.

What Makes a Top Python Development Company?

Understanding why each company has earned its place on our list is crucial. Here’s what sets a leading Python development company apart in the U.S.:

• Experience and Expertise: A strong team of skilled Python developers who have worked on diverse projects, from startups to enterprise-level systems. Years of hands-on coding experience help them architect scalable, efficient, and secure solutions.
• Niche Specialisation: Some companies excel in web frameworks like Django and Flask, while others stand out in AI/ML, fintech, healthcare, or SaaS development. Knowing their specialization helps you find the right fit for your project.
• Technology Stack and Strategy: A top firm will leverage the latest Python tools, frameworks, and libraries while tailoring solutions to your specific needs. They’ll combine technical precision with a strategic approach that aligns with your goals.
• Proven Results: Look for case studies and client success stories. A reliable Python development company should be able to showcase measurable results—whether that’s improved performance, reduced costs, or accelerated time to market.

When evaluating companies, trust your instincts. If something feels off during consultations, keep exploring other options. Now that you know what to look for, let’s explore the top Python development companies in the U.S.

Top Python Development Companies in the U.S.

1. 6B

6B isn’t just your average software development company.

We believe in the power of performance-driven, scalable solutions to help businesses unlock new opportunities with Python development—whether for AI, automation, data engineering, or web applications.

Here’s how we help organisations with Python development:

• Custom Software Development: From enterprise-grade applications to startup MVPs, we build tailored Python solutions that align with your business goals.
• Web Applications: Leveraging frameworks like Django and Flask, we deliver robust, secure, and high-performing web platforms.
• AI & Machine Learning: Our team harnesses Python’s extensive ecosystem to develop intelligent systems that process data, provide insights, and power automation.
• Data Engineering & Integration: We design pipelines and integrate complex systems to ensure data flows seamlessly across your business.
• Automation Solutions: We streamline workflows with Python scripts and tools that save time, reduce costs, and improve efficiency.

What sets us apart?

We’ve established ourselves as specialists in creating performance-driven solutions with Python, trusted by organisations across industries in both the U.S. and Europe.

Our track record speaks for itself—delivering measurable results for clients by building scalable architectures, implementing complex integrations, and accelerating digital transformation.

What truly sets us apart is our commitment to transparency, collaborative development, and providing deep technical expertise supported by a multidisciplinary team.

About Us:

• Dedicated Team: 6B has a growing team of 50+ developers, engineers, and strategists.
• Proven Expertise: Recognised for delivering high-impact software solutions across sectors like healthcare, fintech, and government.
• Global Reach: With headquarters in the UK and clients across the U.S., we bridge international expertise with local support.

If you’re looking for a Python development company in the US that delivers results – click the button below to get in touch. Or, if you’d like to learn more about our Python development services, then check out our service page here.

Get in touch with our Python Development team

2. STX Next

STX Next is a software engineering consultancy with deep specialisation in Python development. Since its founding in 2005, the company has built its core around Python, using it for web back-ends, data engineering, AI/ML work, and scalable custom software. Their teams follow agile practices, emphasise clean, maintainable code, and combine Python with cloud infrastructure, DevOps, and testing to deliver robust, quality solutions.

In the United States, STX Next maintains an office in Spring, Texas, housed in Houston’s City Place. That U.S. presence supports their ability to work with American clients on Python-based projects—covering everything from AI development and data engineering to cloud deployment and product development—while offering local engagement and time-zone convenience.

3. Django Stars

Django Stars is a company that strongly specialises in Python-based development work. They offer end-to-end services including custom application development, web and API development (using frameworks like Django and Flask), automation, AI/ML and data-science solutions. Their workflow emphasises clean architecture, modularity, scalability, and tools like CI/CD, containerisation, and cloud deployment to support robust, maintainable systems.

In the United States, Django Stars has an address in Wilmington, Delaware. This U.S. presence enables them to engage with American clients more directly, facilitating collaboration, communication, and support across time zones, especially for mid- or large-scale projects that need ongoing involvement.

4. Bitcot

Bitcot is a software development company based in San Diego, California, that offers a wide range of Python-based services. Their expertise includes building web applications using frameworks like Django and Flask; developing APIs; automation; data analytics; scraping; AI and machine learning; integration with cloud services such as AWS (via Boto3); and delivering both lightweight and enterprise-scale projects. They emphasise scalable, business-focused solutions, maintainable codebases, and long-term partnerships.

Their main U.S. presence is their headquarters in San Diego, California. With this base, they serve clients in California and across the U.S., offering local support, consultations, and fast turnaround times for U.S.-based projects.

5. Digis

Digis offers extensive Python development services, positioning itself as a specialist in outsourced, offshore, and dedicated-developer models. Their Python work spans web back-ends, API development, data analysis, custom migrations, MVPs, machine learning, and more. They use frameworks and tools such as Django, Flask, FastAPI; integrate with various databases; and work with modern cloud providers ensuring scalable, secure, maintainable code. They also offer trial periods, fast onboarding, and flexible staffing to match clients’ needs.

In the United States, Digis has a physical presence at 641 Lexington Avenue, 14th Floor, New York, NY, 10022. This U.S. office provides local contact points, support, and access to U.S. time zones for coordination with American clients.

6. Lucent Innovation

Lucent Innovation specialises in Python development, offering services in areas such as web & API development (using frameworks like Django and Flask), machine learning / AI, data engineering, RESTful integrations, cloud and IoT integration, plus MVP/prototyping and custom software. Their Python-teams emphasise security, scalability, clean architecture, and performance, making sure solutions are future-proof with tools like Docker, Kubernetes, and modern cloud technologies.

In the U.S., Lucent Innovation has a presence in Wilmington, Delaware, where one of their offices is located. This gives them a foothold to serve American clients more directly, facilitating collaboration in U.S. time zones and enabling more immediate support, local meetings, or coordination when required.

7. Zibtek

Zibtek is a U.S.-based custom software development company with strong capabilities in Python back-end work. Their services include Python web development using frameworks such as Django, API development, staff augmentation, web & mobile backend, and integrations. They emphasise high-value, maintainable software, user-centric design, and deep experience, having delivered “hundreds of projects” in Python.

Their main U.S. address is 14193 South Minuteman Drive, Suite 100, Draper, Utah 84020. With this presence, they support clients directly within U.S. time zones and provide local contact points for ongoing project collaboration, support, and stakeholder communication.

8. Zazz

Zazz offers comprehensive Python application development, using Python for web and mobile back-ends, custom development, CMS work, migration to newer Python versions, and machine learning. Their team emphasises building scalable, secure, feature-rich applications using Django (and likely related frameworks), with agile processes and transparent development cycles. They also support UI/UX design, prototyping, and ongoing technical support post-launch.

In the U.S., Zazz has multiple offices, including locations in San Francisco, California; Boston, Massachusetts; New York, New York; Seattle, Washington; and Dallas, Texas. This multi-city presence enables them to engage with clients across different U.S. time zones and offer local touchpoints for collaboration, meetings, and support.

9. Scadea

Scadea offers a broad spectrum of Python development services, including custom web applications, AI and machine learning solutions, data science and analytics, CMS development (using frameworks like Django, Flask), mobile apps using Python-compatible frameworks, and cloud-based solutions. Their approach emphasises scalability, security, maintainability, and agile workflows, with flexible engagement models and full lifecycle support.

Their U.S. headquarters is located at 3490 US Highway 1, Suite 11, Princeton, New Jersey. That base gives them a foothold for working closely with American clients, enabling coordination in U.S. time zones, local contact, and support throughout project delivery.

10. Capsquery

CapsQuery likely provides standard Python development services including web back-end development (Django / Flask), API building, integration, automation, and possibly data analysis or scripting tools. Their teams probably emphasise clean architecture, maintainability, and collaboration, enabling flexible deployment via cloud platforms or containerisation to meet client needs.

I was unable to verify a U.S. location for their Python development services due to access issues. If you like, I can try alternative sources or domain records to confirm whether they have a U.S. office or presence for local operations.

11. Radixweb

Radixweb offers a broad suite of Python development services, including web app development (using frameworks like Django, Flask), API development, mobile-backend work, CMS setups, machine learning, and legacy system modernisation. Their teams employ agile methodologies and enterprise-grade best practices to build scalable, reliable, maintainable solutions for clients ranging from startups to large organisations.

In the U.S., Radixweb has offices in Artesia, California, and Frisco, Texas. These locations allow them to provide clients with local touchpoints, align more conveniently with U.S. time zones, and offer direct support and collaboration for domestic projects.

12. iQlance Solutions

iQlance Solutions offers Python development services, delivering scalable, robust, high-performance applications with clean code practices and modern frameworks. They provide backend APIs, dynamic web apps, integrations, possibly AI/ML & automation work. Their service includes hiring dedicated Python developers, flexible deployment models, and working with U.S. and international clients.

In the United States, iQlance has offices in Dallas, Texas (17250 Dallas Parkway) and New York, New York. Their U.S. locations allow for better alignment with U.S. time zones, more direct collaboration with American clients, and localised points of contact for project management and support.

13. Innvonix

Innvonix provides end-to-end Python development expertise, offering services such as custom web application development (using Django, Flask, FastAPI), mobile back-end work, CMS development, migration & upgrading of Python applications, and AI/ML solutions. Their teams follow modern best practices (including PEP-8, scalable and secure architectures) and also offer flexible engagement models (full-time, part-time, hourly). They aim for swift prototyping and maintainable, enterprise-grade code.

In the United States, Innvonix has a sales / contact office at 5 Penn Plaza, Suite 1918, New York, NY 10001. This U.S. location provides a point of local contact, helping American clients engage with them more smoothly, coordinate across time zones, and receive support more directly.

14. Clarion Technologies

Clarion Tech offers comprehensive Python development, including web-application and API development using frameworks like Django, Flask, FastAPI, web2py and others. Their services cover custom apps, migration of legacy systems, IoT, data engineering, microservices, chatbots/virtual assistants and Python GUI work. They emphasise clean architecture, scalability, security, rapid development cycles, and having devoted Python developers with substantial experience.

In the U.S., Clarion Tech maintains an office at 50 Main Street, Suite 1000, White Plains, New York 10606. This U.S. base enables them to work directly with American clients, aligning across U.S. time zones, offering localised communication and better support for ongoing projects.

15. Biz4Group

Biz4Group offers end-to-end Python development services, covering everything from consulting, custom web and mobile applications, API design, migration of legacy systems, to AI/ML-enabled automation. Their teams use popular Python frameworks like Django, Flask, FastAPI, emphasise clean, maintainable code, strong testing (both automated and manual), and work under agile processes. They also provide post-launch support, performance optimisation, and solutions tailored by industry: healthcare, fintech, eCommerce and more.

They are based in the United States with their U.S. address in Orlando, Florida (7380 W Sand Lake Rd #500). Because they are U.S.-based, they are able to offer time-zone aligned collaboration, local communication, and leadership in the U.S., making coordination with American clients smoother and more direct.

Why Hire One of the Best Python Development Companies in the U.S.?

In today’s highly competitive U.S. tech landscape, having a reliable and skilled Python development partner is essential for building scalable, secure, and innovative solutions. The right company brings the expertise, tools, and proven strategies to ensure your project not only meets expectations but exceeds them.

Top Python development companies tailor their services to both established enterprises and fast-growing startups, helping them build everything from AI-driven platforms to custom web applications. Whether you need rapid prototyping, complex integrations, or end-to-end development, partnering with the best ensures your goals are met efficiently and effectively.

To explore the possibilities for your project, reach out to a trusted Python development company today and take the first step toward building something extraordinary.

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